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Once inside the cells, enzymes remove the acetyl group, restoring it to fully active glutathione

Detection of 5-S-cysteinyldopamine in human brain

Ushimaru et al., 2006

Its main function is to neutralize free radicals, detoxify the body, and support immune health

However, senkyunolides not only act on the aforementioned neurovascular targets but, more importantly, are involved in multidimensional homeostatic regulation of the neurovascular unit (by suppressing activation of the trigeminal vascular system, modulating pathological vascular alterations, modulating neurotransmitters and receptors, inhibiting inflammatory response, counteracting oxidative stress, producing analgesic effects, and improving BBB integrity) (Figure 1)

[DOI] [PMC free article] [PubMed] [Google Scholar] Chaplin DD (2010) Overview of the immune response